tailieunhanh - Báo cáo y học: " Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury. | Critical Care February 2005 Vol 9 No 1 Zhang et al. Review Bench-to-bedside review Apoptosis programmed cell death triggered by traumatic brain injury Xiaopeng Zhang1 Yaming Chen2 Larry W Jenkins3 Patrick M Kochanek4 and Robert SB Clark5 Assistant Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Safar Center for Resuscitation Research Pittsburgh PA USA 2Research Associate Department of Critical Care Medicine University of Pittsburgh School of Medicine Safar Center for Resuscitation Research Pittsburgh PA USA 3Associate Professor Department of Neurological Surgery University of Pittsburgh School of Medicine Safar Center for Resuscitation Research Pittsburgh PA USA 4Professor Departments of Critical Care Medicine and Pediatrics University of Pittsburgh School of Medicine Safar Center for Resuscitation Research Pittsburgh PA USA 5Associate Professor Departments of Critical Care Medicine and Pediatrics University of Pittsburgh School of Medicine Safar Center for Resuscitation Research Pittsburgh PA USA Corresponding author Robert SB Clark clarkrs@ Published online 3 September 2004 This article is online at http content 9 1 66 2004 BioMed Central Ltd Critical Care 2005 9 66-75 DOI cc2950 Abstract Apoptosis or programmed cell death is a physiological form of cell death that is important for normal embryologic development and cell turnover in adult organisms. Cumulative evidence suggests that apoptosis can also be triggered in tissues without a high rate of cell turnover including those within the central nervous system CNS . In fact a crucial role for apoptosis in delayed neuronal loss after both acute and chronic CNS injury is emerging. In the current review we summarize the growing evidence that apoptosis occurs after traumatic brain injury TBI from experimental models to humans. This includes the identification of apoptosis after TBI initiators of apoptosis key modulators of apoptosis such as .