tailieunhanh - Báo cáo y học: "Erythropoietin in the critically ill – is it more than just blood"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Erythropoietin in the critically ill – is it more than just blood? | Available online http content 8 5 325 Commentary Erythropoietin in the critically ill - is it more than just blood Howard L Corwin Professor of Medicine and Anesthesiology Dartmouth Medical School Section Chief Critical Care Medicine Medical Director Intensive Care Unit Dartmouth-Hitchcock Medical Center Lebanon New Hampshire USA Corresponding author Howard L Corwin Published online 6 September 2004 This article is online at http content 8 5 325 2004 BioMed Central Ltd See Review page 337 Critical Care 2004 8 325-326 DOI cc2949 Abstract Erythropoietin EPO has been in clinical use for the treatment of anemia for over 15 years. Recently it has been demonstrated that EPO has actions other than stimulating the bone marrow. It has been suggested that due to its tissue protecting effect EPO may be effective in improving outcome in the critically ill. Keywords apoptosis erythropoietin sepsis Recombinant human erythropoietin EPO has been in widespread clinical use for over 15 years. Initially employed for the treatment of anemia associated chronic renal failure it has now been demonstrated to be effective in treating anemia in a variety of other clinical settings including HIV cancer surgery and most recently critical illness 1 . Over the past several years it has become apparent that EPO has actions other than just stimulating bone marrow to produce mature erythrocytes. EPO is also a cytokine with important antiapoptotic activity 2 . In this latter role EPO has been demonstrated to confer important tissue protection in preclinical and some clinical studies 3-6 . In their excellent review in this issue of Critical Care Coleman and Brines 7 provide a succinct discussion of the nonhematologic actions of EPO in protecting tissues and raise the intriguing possibility of clinical use of EPO to protect tissues in the critically ill. Apoptosis is important in the pathogenesis of many critical illnesses such as sepsis .