tailieunhanh - Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : The application of carbon nanotubes in target drug delivery systems for cancer therapies | Zhang et al. Nanoscale Research Letters 2011 6 555 http content 6 1 555 o Nanoscale Research Letters a SpringerOpen Journal NANO REVIEW Open Access The application of carbon nanotubes in target drug delivery systems for cancer therapies Wuxu Zhang1 Zhenzhong Zhang2 and Yingge Zhang1 Abstract Among all cancer treatment options chemotherapy continues to play a major role in killing free cancer cells and removing undetectable tumor micro-focuses. Although chemotherapies are successful in some cases systemic toxicity may develop at the same time due to lack of selectivity of the drugs for cancer tissues and cells which often leads to the failure of chemotherapies. Obviously the therapeutic effects will be revolutionarily improved if human can deliver the anticancer drugs with high selectivity to cancer cells or cancer tissues. This selective delivery of the drugs has been called target treatment. To realize target treatment the first step of the strategies is to build up effective target drug delivery systems. Generally speaking such a system is often made up of the carriers and drugs of which the carriers play the roles of target delivery. An ideal carrier for target drug delivery systems should have three pre-requisites for their functions 1 they themselves have target effects 2 they have sufficiently strong adsorptive effects for anticancer drugs to ensure they can transport the drugs to the effect-relevant sites and 3 they can release the drugs from them in the effect-relevant sites and only in this way can the treatment effects develop. The transporting capabilities of carbon nanotubes combined with appropriate surface modifications and their unique physicochemical properties show great promise to meet the three pre-requisites. Here we review the progress in the study on the application of carbon nanotubes as target carriers in drug delivery systems for cancer therapies. Keywords carbon nanotubes cancer therapies drug delivery systems .

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