tailieunhanh - Báo cáo y học: " Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids,,, | Journal of Inflammation BioMed Central Open Access Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids Lucia Rackova 1 Marek Oblozinsky2 Daniela Kostalova3 Viktor Kettmann4 and Lydia Bezakova3 Address institute of Experimental Pharmacology Slovak Academy of Sciences Dúbravská cesta 9 SK-841 04 Bratislava Slovakia 2Department of Cell and Molecular Biology of Drugs Faculty of Pharmacy Comenius University Odbojarov 10 SK-83232 Bratislava Slovakia 3Department of Pharmacognosy and Botany Faculty of Pharmacy Comenius University Odbojárov 10 SK-83232 Bratislava Slovakia and 4Department of Pharmaceutical Analysis and Nuclear Pharmacy Faculty of Pharmacy Comenius University Odbojárov 10 SK-83232 Bratislava Slovakia Email Lucia Rackova - exfadada@ Marek Oblozinsky-OBLOZINSKY@ Daniela Kostalova - kostalova@ Viktor Kettmann - kettmann@ Lydia Bezakova - BEZAKOVA@ Corresponding author Published 16 July 2007 Journal of Inflammation 2007 4 15 doi 1476-9255-4-15 Received 8 February 2006 Accepted 16 July 2007 This article is available from http content 4 1 15 2007 Rackova et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Roots and stem-bark of Mahonia aquifolium Oregon grape Berberidaceae are effectively used in the treatment of skin inflammatory conditions. In the present study the effect of Mahonia aquifolium crude extract and its two representative alkaloid fractions containing protoberberine and bisbenzylisoquinoline BBIQ alkaloids on activity of 12-lipoxygenase 12-LOX was studied. The reactivity with 1 1-diphenyl-2-picryl-hydrazyl DPPH a free stable .