tailieunhanh - Báo cáo y học: "Dantrolene and heatstroke: a good molecule applied in an unsuitable situation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Dantrolene and heatstroke: a good molecule applied in an unsuitable situation. | Available online http content 9 1 23 Commentary Dantrolene and heatstroke a good molecule applied in an unsuitable situation Pierre Hausfater MD Service d accueil des urgences Centre Hospitalier Universitaire Pitié-Salpêtrière Assistance Publique-Hôpitaux de Paris Université Pierre et Marie Curie Paris France Corresponding author Dr Pierre Hausfater Published online 3 September 2004 This article is online at http content 9 1 23 2004 BioMed Central Ltd See Review page 86 Critical Care 2005 9 23-24 DOI cc2939 Abstract Because they share one pathognomonic sign major hyperthermia classic or environmental heatstroke and malignant hyperthermia have often been confronted from the therapeutic point of view. As expected and according to major physiopathological discrepancies between both syndromes analysis of published data does not support effectiveness of dantrolene in heatstroke despite its significant reduction in mortality in malignant hyperthermia. If cooling methods still represent the cornerstone of the heatstroke therapeutic approach the magnitude of heat-related deaths and the morbidity associated with the August 2003 French heatwave have highlighted the need for more ambitious methods of treatment. Keywords dantrolene health care heatstroke heatwave malignant hyperthermia The magnitude of heat-related deaths during the August 2003 heatwave in France and conflicting discussions about Earth s global warming consequences have forced physicians to revisit an up to now rare disease classic or environmental heatstroke CHS 1 2 . Indeed most reported cases of CHS are sporadic except for a few previously published epidemics linked to unusual heatwaves 3 4 . The CHS therapeutic approach to date has therefore been limited to human case reports or experimental data on animal models. CHS is often compared with other extreme hyperthermia syndromes such as malignant hyperthermia and neuroleptic malignant .

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