tailieunhanh - Báo cáo y học: "Anti-inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of Providencia and San Andrés (SW Caribbean)"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Anti-inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of Providencia and San Andrés (SW Caribbean). | Journal of Inflammation BioMed Central Open Access Anti-inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of Providencia and San Andrés SW Caribbean Hebelin Correa1 Alba Lucia Valenzuela2 Luis Fernando Ospina 2 and Carmenza Duque 1 Address 1Departamento de Química Universidad Nacional de Colombia Cra. 30 N 45 -03 Bogotá Colombia and 2Departamento de Farmacia Universidad Nacional de Colombia Cra. 30 N 45 -03 Bogotá Colombia Email Hebelin Correa - hcorreav@ Alba Lucia Valenzuela - alvalenzuelac@ Luis Fernando Ospina - lfospinag@ Carmenza Duque - cduqueb@ Corresponding authors Published 10 March 2009 Received 25 September 2008 Accepted 10 March 2009 Journal of Inflammation 2009 6 5 doi l476-9255-6-5 This article is available from http content 6 1 5 2009 Correa et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We are reporting for the first time the in vivo anti-inflammatory activity of extracts and fractions and in vitro anti-inflammatory activity of pure compounds all isolated from Pseudopterogorgia elisabethae collected at the Providencia chemotype 1 and San Andrés chemotype 2 Islands SW Caribbean . Methods Extracts from P. elisabethae were fractionated on silica gel to yield fractions F-1 pseudopterosins PsQ PsS and PsU and F-2 amphilectosins A and B PsG PsK PsP and PsT and seco-pseudopterosins seco-PsJ and seco-PsK from chemotype 1 and F-3 elisabethatrienol 1 0-acetoxy-9-hydroxy- and 9-acetoxy-10-hydroxy-amphilecta-8 10 12 14-tetraenes interconverting mixture and amphilecta-8 13 11 14-triene-9 10-dione from chemotype 2. By using preparative RP-HPLC and spectroscopic .

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