tailieunhanh - Báo cáo y học: " Science review: Searching for gene candidates in acute lung injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Science review: Searching for gene candidates in acute lung injury. | Critical Care December 2004 Vol 8 No 6 Grigoryev et al. Review Science review Searching for gene candidates in acute lung injury Dmitry N Grigoryev1 James H Finigan1 Paul Hassoun2 and Joe GN Garcia3 1 Fellow Center for Translational Respiratory Medicine Division of Pulmonary and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA 2Associate Professor Center for Translational Respiratory Medicine Division of Pulmonary and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA 3Director Center for Translational Respiratory Medicine Division of Pulmonary and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA Corresponding author Joe GN Garcia drgarcia@ Published online 30 June 2004 This article is online at http content 8 6 440 2004 BioMed Central Ltd Critical Care 2004 8 440-447 DOI cc2901 See Commentary page 411 Abstract Acute lung injury ALI is a complex and devastating illness often occurring within the setting of sepsis and carries an annual mortality rate of 30-50 . Although the genetic basis of ALI has not been fully established an increasing body of evidence suggests that genetic predisposition contributes to disease susceptibility and severity. Significant difficulty exists however in defining the exact nature of these genetic factors including large phenotypic variance incomplete penetrance complex gene-environment interactions and strong potential for locus heterogeneity. We utilized the candidate gene approach and an ortholog gene database to provide relevant gene ontologies and insights into the genetic basis of ALI. We employed a Medline search of selected basic and clinical studies in the English literature and studies sponsored by the HopGene National Institutes of Health sponsored Program in Genomic Applications. Extensive gene expression profiling studies in animal models of ALI rat murine canine as well as in .