tailieunhanh - Báo cáo y học: "CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis. | Bhagawati-Prasad et al. Journal of Immune Based Therapies and Vaccines 2010 8 1 http content 8 1 1 JOURNAL OF IMMUNE BASED THERAPIES AND VACCINES SHORT REPORT Open Access CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis 1 f 1 f 1 1 1 Vijay NS Bhagawati-Prasad Evy De Leenheer Nadine P Keefe Lorna A Ryan Jennifer Carlring Andrew W Heath1 2 Abstract Active vaccination can be effective as a post-exposure prophylaxis but the rapidity of the immune response induced relative to the incubation time of the pathogen is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants alum and monophosphoryl lipid A . Findings Post-exposure prophylaxis PEP or the induction of protection against an infectious disease after exposure to the pathogen is either utilised or has been suggested as an appropriate course of action for a number of diseases including rabies 1 anthrax 2 varicella 3 4 HIV and Hepatitis A 5 . PEP can be divided into three categories The administration of antibiotics or antivirals passive immunization using specific immunoglobulin and active immunization vaccination . In some cases appropriate antimicrobial chemotherapy may not be available or there may be a worry that the pathogen could be resistant to the agent particularly in bioterrorism cases. Passive immunization using immunoglobulin may be a suitable alternative if the pathogen is susceptible to antibody-mediated killing. However active vaccination has the potential advantages of lower cost less risk of adventitious pathogen transfer and most importantly the induction of long-term protection. The use of active vaccination as PEP however depends upon the rapidity with which a protective immune response can be generated in comparison with the incubation period of the pathogen p ost-exposure. The kinetics of the immune response are therefore a .

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