tailieunhanh - Báo cáo y học: "Early Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study. | Journal of Inflammation BioMed Central Research Open Access Effects of anti-inflammatory I 2 4 triazolo 4 3-a I 8 naphthyridine derivatives on human stimulated PMN and endothelial cells an in vitro study Chiara Dianzani t1 Massimo Collinot1 Margherita Gallicchio1 Mario Di Braccio2 Giorgio Roma2 and Roberto Fantozzi1 Address Department of Anatomy Pharmacology and Forensic Medicine University of Turin V P Giuria 9 10125 Torino Italy and 2Department of Pharmaceutical Sciences University of Genoa Viale Benedetto XV 3 16132 Genoa Italy Email Chiara Dianzani - Massimo Collino - Margherita Gallicchio - Mario Di Braccio - dbraccio@ Giorgio Roma - roma@ Roberto Fantozzi - Corresponding author tEqual contributors Published 28 March 2006 Received 18 November 2005 Accepted 28 March 2006 Journal of Inflammation2006 3 4 doi l476-9255-3-4 This article is available from http content 3 1 4 2006Dianzani et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background 1 2 4 triazolo 4 3-a 1 8 naphthyridine derivatives including NF161 and NF177 were tested for antiinflammatory analgesic and antipyretic properties and for their effects on spontaneous locomotor activity in mice and acute gastrolesivity in rats. Both NF161 and NF177 appeared to be anti-inflammatory and analgesic agents without toxic effects or acute gastrolesivity but NF161 showed stronger anti-inflammatory activity whereas NF177 was more active as analgesic. Methods An EIA kit was used to investigate the ability of NF161 and NF177 to affect prostaglandin E2 PGE2 and prostacyclin PGI2 production by human umbilical