tailieunhanh - Báo cáo y học: "Serum cystatin C concentration as a marker of acute renal dysfunction in critically ill patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Serum cystatin C concentration as a marker of acute renal dysfunction in critically ill patients. | Available online http content 9 2 R139 Research Serum cystatin C concentration as a marker of acute renal dysfunction in critically ill patients Patricia Villa1 Manuel Jimenez1 Maria-Cruz Soriano1 Jesus Manzanares1 and Pilar Casasnovas2 Open Access intensive Care Unit Hospital Universitario La Paz Madrid Spain 2Biochemistry Unit Hospital Universitario La Paz Madrid Spain Corresponding author Manuel Jiménez majilen@ Received 4 June 2004 Revisions requested 26 July 2004 Revisions received 25 October 2004 Accepted 17 December 2004 Published 7 February 2005 Critical Care 2005 9 R139-R143 DOI cc3044 This article is online at http content 9 2 R139 2005 Villa et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction In critically ill patients sudden changes in glomerular filtration rate GFR are not instantly followed by parallel changes in serum creatinine. The aim of the present study was to analyze the utility of serum cystatin C as a marker of renal function in these patients. Methods Serum creatinine serum cystatin C and 24-hour creatinine clearance CCr were determined in 50 critically ill patients age 21-86 years mean Acute Physiology and Chronic Health Evaluation II score 20 9 . They did not have chronic renal failure but were at risk for developing renal dysfunction. Serum cystatin C was measured using particle enhanced immunonephelometry. Twenty-four-hour body surface adjusted CCr was used as a control because it is the gold standard for determining GFR. Results Serum creatinine serum cystatin C and CCr mean standard deviation range were mg dl mg dl mg l mg l and ml min per m2 ml min per m2 .