tailieunhanh - Báo cáo y học: "Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study. | Available online http content 9 1 R37 Re search Pro-atrial natriuretic peptide is a prognostic marker in sepsis similar to the APACHE II score an observational study Nils G Morgenthaler1 Joachim Struck1 Mirjam Christ-Crain2 Andreas Bergmann1 and Beat Muller2 Open Access Research Department BRAHMS AG Biotechnology Center Hennigsdorf Berlin Germany 2Department of Internal Medicine University Hospital Basel Switzerland Corresponding author Beat Muller happymiller@ Received 7 September 2004 Revisions requested 12 October 2004 Revisions received 4 November 2004 Accepted 5 November 2004 Published 17 December 2004 Critical Care 2005 9 R37-R45 DOI cc3015 This article is online at http content 9 1 R37 2004 Morgenthaler et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Abstract Introduction Additional biomarkers in sepsis are needed to tackle the challenges of determining prognosis and optimizing selection of high-risk patients for application of therapy. In the present study conducted in a cohort of medical intensive care unit patients our aim was to compare the prognostic value of mid-regional pro-atrial natriuretic peptide ANP levels with those of other biomarkers and physiological scores. Methods Blood samples obtained in a prospective observational study conducted in 101 consecutive critically ill patients admitted to the intensive care unit were analyzed. The prognostic value of pro-ANP levels was compared with that of the Acute Physiology and Chronic Health Evaluation APACHE II score and with those of various biomarkers . C-reactive protein IL-6 and procalcitonin . Mid-regional pro-ANP was detected in EDTA plasma from all patients using a new sandwich immunoassay. Results On admission