tailieunhanh - Báo cáo khoa học: "Bench-to-bedside review: Acute respiratory distress syndrome – how neutrophils migrate into the lung"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Acute respiratory distress syndrome – how neutrophils migrate into the lung. | Available online http content 8 6 453 Review Bench-to-bedside review Acute respiratory distress syndrome -how neutrophils migrate into the lung Jorg Reutershan1 and Klaus Ley2 1 Research Associate University of Virginia Health System Cardiovascular Research Center Charlottesville Virginia USA and Department of Anesthesiology and Intensive Care Medicine University of Tubingen Tubingen Germany 2Professor of Biomedical Engineering Molecular Physiology and Biological Physics University of Virginia Health System Cardiovascular Research Center Charlottesville Virginia USA Corresponding author Klaus Ley klausley@ Published online 3 June 2004 This article is online at http content 8 6 453 2004 BioMed Central Ltd Critical Care 2004 8 453-461 DOI cc2881 Abstract Acute lung injury and its more severe form acute respiratory distress syndrome are major challenges in critically ill patients. Activation of circulating neutrophils and transmigration into the alveolar airspace are associated with development of acute lung injury and inhibitors of neutrophil recruitment attenuate lung damage in many experimental models. The molecular mechanisms of neutrophil recruitment in the lung differ fundamentally from those in other tissues. Distinct signals appear to regulate neutrophil passage from the intravascular into the interstitial and alveolar compartments. Entry into the alveolar compartment is under the control of CXC chemokine receptor CXCR 2 and its ligands CXC chemokine ligand CXCL 1-8 . The mechanisms that govern neutrophil sequestration into the vascular compartment of the lung involve changes in the actin cytoskeleton and adhesion molecules including selectins P2 integrins and intercellular adhesion molecule-1. The mechanisms of neutrophil entry into the lung interstitial space are currently unknown. This review summarizes mechanisms of neutrophil trafficking in the inflamed lung and their relevance to lung injury. Keywords acute .