tailieunhanh - Báo cáo khoa học: " Effects of volume resuscitation on splanchnic perfusion in canine model of severe sepsis induced by live Escherichia coli infusio"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effects of volume resuscitation on splanchnic perfusion in canine model of severe sepsis induced by live Escherichia coli infusion. | Available online http content 8 4 R221 Research Effects of volume resuscitation on splanchnic perfusion in canine model of severe sepsis induced by live Escherichia coli infusion Claudio Esteves Lagoa1 Luiz Francisco Poli de Figueiredo2 Ruy Jorge Cruz Jr3 Eliezer Silva4 and Mauricio Rocha e Silva5 Open Access 1DVM Fellow Division of Applied Physiology Heart Institute InCor University of São Paulo Medical School São Paulo Brazil 2Associate Professor Division of Applied Physiology Heart Institute InCor University of São Paulo Medical School São Paulo Brazil 3Assistant Physician Division of Applied Physiology Heart Institute InCor University of São Paulo Medical School São Paulo Brazil 4Visiting Professor Division of Applied Physiology Heart Institute InCor University of São Paulo Medical School São Paulo Brazil 5Chairman Division of Applied Physiology Heart Institute InCor University of São Paulo Medical School São Paulo Brazil Corresponding author Luiz Francisco Poli de Figueiredo lpoli@ Received 30 October 2003 Revisions requested 22 December 2003 Revisions received 14 April 2004 Accepted 21 April 2004 Published 27 May 2004 Critical Care 2004 8 R221-R228 DOI cc2871 This article is online at http content 8 4 R221 2004 Lagoa et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Introduction We conducted the present study to investigate whether early large-volume crystalloid infusion can restore gut mucosal blood flow and mesenteric oxygen metabolism in severe sepsis. Methods Anesthetized and mechanically ventilated male mongrel dogs were challenged with intravenous injection of live Escherichia coli 6 X 109 colony-forming units ml per kg over 15 min . After 90 min they were randomly assigned to one of two groups - control no fluids n 13 or