tailieunhanh - Báo cáo khoa học: "Can generic paediatric mortality scores calculated 4 hours after admission be used as inclusion criteria for clinical trials"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Can generic paediatric mortality scores calculated 4 hours after admission be used as inclusion criteria for clinical trials? | Available online http content 8 4 R185 Research Can generic paediatric mortality scores calculated 4 hours after admission be used as inclusion criteria for clinical trials Stéphane Leteurtre1 Francis Leclerc2 Jessica Wirth3 Odile Noizet4 Eric Magnenant4 Ahmed Sadik5 Catherine Fourier5 and Robin Cremer5 Open Access Paediatric Intensivist Paediatric Intensive Care Unit University Hospital of Lille and SAMU Lille France 2Professor Director Paediatric Intensive Care Unit University Hospital of Lille Lille France 3Resident Paediatric Intensive Care Unit University Hospital of Lille Lille France 4Clinical Fellow Paediatric Intensive Care Unit University Hospital of Lille Lille France 5Paediatric Intensivist Paediatric Intensive Care Unit University Hospital of Lille Lille France Corresponding author Francis Leclerc fleclerc@ Received 07 November 2003 Revisions requested 16 January 2004 Revisions received 07 April 2004 Accepted 20 April 2004 Published 21 May 2004 Critical Care 2004 8 R185-R193 DOI cc2869 This article is online at http content 8 4 R185 2004 Leteurtre et al. Licensee Biomed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Introduction Two generic paediatric mortality scoring systems have been validated in the paediatric intensive care unit PICU . Paediatric RISk of Mortality PRISM requires an observation period of 24 hours and PRISM III measures severity at two time points at 12 hours and 24 hours after admission which represents a limitation for clinical trials that require earlier inclusion. The Paediatric Index of Mortality PIM is calculated 1 hour after admission but does not take into account the stabilization period following admission. To avoid these limitations we chose to conduct assessments 4 hours after PICU admission. The aim of .