tailieunhanh - Báo cáo y học: "Cellular infiltrates and injury evaluation in a rat model of warm pulmonary ischemia–reperfusion"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Cellular infiltrates and injury evaluation in a rat model of warm pulmonary ischemia–reperfusion. | Available online http content 9 1 R1 Re search Cellular infiltrates and injury evaluation in a rat model of warm pulmonary ischemia-reperfusion Bart P Van Putte1 2 Jozef Kesecioglu3 4 Jeroen MH Hendriks1 Veerle P Persy4 Erik van Marck5 Paul EY Van Schil1 and Marc E De Broe6 Open Access 1 Department of Thoracic and Vascular Surgery University Hospital Antwerp Antwerp Belgium 2Department of Cardiothoracic Surgery University Medical Center Utrecht The Netherlands intensive Care Center University Medical Center Utrecht The Netherlands 4Division of Perioperative Medicine and Emergency Care University Medical Center Utrecht The Netherlands 5Department of Pathology University Hospital Antwerp Antwerp Belgium 6Department of Nephrology University Hospital Antwerp Antwerp Belgium Corresponding author Bart P Van Putte bvanputte@ Received 24 June 2004 Revisions requested 17 September 2004 Revisions received 24 September 2004 Accepted 7 October 2004 Published 10 November 2004 Critical Care 2005 9 R1-R8 DOI cc2992 This article is online at http content 9 1 R1 2004 Van Putte et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Beside lung transplantation cardiopulmonary bypass isolated lung perfusion and sleeve resection result in serious pulmonary ischemia-reperfusion injury clinically known as acute respiratory distress syndrome. Very little is known about cells infiltrating the lung during ischemia-reperfusion. Therefore a model of warm ischemia-reperfusion injury was applied to differentiate cellular infiltrates and to quantify tissue damage. Methods Fifty rats were randomized into eight groups. Five groups underwent warm ischemia for 60 min followed by 30 min and 1-4 .