tailieunhanh - Báo cáo khoa học: " Bench-to-bedside review: Understanding genetic predisposition to sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Understanding genetic predisposition to sepsis. | Critical Care June 2004 Vol 8 No 3 Villar et al. Review Bench-to-bedside review Understanding genetic predisposition to sepsis Jesus Villar1 2 3 Nicole Maca-Meyer4 Lina Pérez-Méndez5 and Carlos Flores4 Director Research Institute and Chairman Division Critical Care Research Research Institute Hospital Universitario NS de Candelaria Tenerife Canary Islands Spain 2Associate Scientist Research Center St Michael s Hospital Toronto Canada 3Clinical Professor Critical Care Medicine Mercer University Macon Georgia USA 4Post-doctoral Research Fellow Division of Genetics Research Institute Hospital Universitario NS de Candelaria Tenerife Canary Islands Spain 5Clinical epidemiologist Division of Epidemiology and Biostatistics Research Institute Hospital Universitario NS de Candelaria Tenerife Canary Islands Spain Corresponding author Jesus Villar Published online 29 April 2004 This article is online at http content 8Z3 180 2004 BioMed Central Ltd Critical Care 2004 8 180-189 DOI cc2863 Abstract Sepsis is a complex syndrome that develops when the initial appropriate host response to an infection becomes amplified and is then dysregulated. Among other factors the innate immune system is of central importance to the early containment of infection. Death from infection is strongly heritable in human populations. Hence genetic variations that disrupt innate immune sensing of infectious organisms could explain the ability of the immune system to respond to infection the diversity of the clinical presentation of sepsis the response to current medical treatment and the genetic predisposition to infection in each individual patient. Such genetic variations may identify patients at high risk for the development of sepsis and organ dysfunction during severe infections. Single base variations known as single nucleotide polymorphisms SNPs are the most commonly used variants. There has been great interest in exploring SNP in those genes .