tailieunhanh - Báo cáo y học: " DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes. | Journal of Immune Based Therapies and Vaccines BioMed Central Original research DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes Rubens R Santos Junior1 2 Alexandrina Sartori3 Deison S Lima1 Patricia RM Souza1 Arlete AM Coelho-Castelo1 Vânia LD Bonato1 and Célio L Silva 1 Address University of São Paulo Ribeirão Preto Medical School Department of Biochemistry and Immunology Ribeirão Preto São Paulo Brazil 2Department of Clinical Analyses School of Pharmaceutical Sciences São Paulo State University Araraquara São Paulo Brazil and 3Bioscience Institute São Paulo State University Botucatu São Paulo Brazil Email Rubens R Santos - santosjr@ Alexandrina Sartori - sartori@ Deison S Lima - deison1@ Patricia RM Souza - souzaprm@ Arlete AM Coelho-Castelo - apcastel@ Vânia LD Bonato - vlbonato@ Célio L Silva - clsilva@ Corresponding author Open Access Published 15 September 2009 Received 22 April 2009 __ _ -r .__ AAQ J . . OCIO-7A Accepted 15 September 2009 Journal ofImmune Based Therapies and Vaccines 2009 7 4 doi 1476-8518-7-4 This article is available from http content 7 1 4 2009 Santos et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Our group previously demonstrated that a DNA plasmid encoding the mycobacterial 65-kDa heat shock protein DNA-HSP65 displayed prophylactic and therapeutic effect in a mice model for tuberculosis. This protection was attributed to induction of a strong cellular immunity against HSP65. As specific immunity to HSP60 family has .