tailieunhanh - Báo cáo khoa học: "Nosocomial infections and immunity: lesson from brain-injured patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Nosocomial infections and immunity: lesson from brain-injured patients. | Critical Care August 2004 Vol 8 No 4 Dziedzic et al. Review Nosocomial infections and immunity lesson from brain-injured patients Tomasz Dziedzic Agnieszka Slowik and Andrzej Szczudlik Department of Neurology Jagiellonian University Krakow Poland Corresponding author Tomasz Dziedzic dziedzictom@ or Dziedzic@ Published online 19 February 2004 Critical Care 2004 8 266-270 DOI cc2828 This article is online at http content 8 4 266 2004 BioMed Central Ltd Abstract Of brain-injured patients admitted to intensive care units a significant number acquires nosocomial infections. Increased susceptibility to infectious agents could at least partly be due to transient immunodepression triggered by brain damage. Immune deficiency in patients with severe brain injury primarily involves T cell dysfunction. However humoral and phagocytic deficiencies are also detectable. Activation of the hypothalamo-pituitary-adrenal axis and the sympathetic nervous system plays a crucial role in brain-mediated immunodepression. In this review we discuss the role of immunodepression in the development of nosocomial infections and clinical trials on immunomodulation in brain-injured patients with hospital-acquired infections. Keywords brain injury immunodepression infection intensive care Introduction An infection that is not present or incubating when a patient is admitted to hospital but is detected 48-72 hours after admission is considered to a nosocomial rather than community-acquired infection 1 . Nosocomial infections affect about 30 of patients in intensive care units ICUs incidence rates range between 9 and 37 depending on the population studied and the definition used 2 . Patients with severe brain injury appear to be at greater risk for nosocomial infections than other ICU patients. In one study 3 41 out of 82 50 patients with severe head injury experienced at least one infectious complication during their hospitalization. Piek and .

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.