tailieunhanh - Báo cáo y học: "Red man syndrome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Red man syndrome. | Available online http content 7 2 119 Commentary Red man syndrome Soupramanien Sivagnanam1 and Dirk Deleu2 Senior Registrar Department of Anaesthesia Intensive Care Sultan Qaboos University Hospital Al Khod Muscat Oman 2Associate Professor Department of Clinical Pharmacology College of Medicine Sultan Qaboos University Al Khod Muscat Oman Correspondence Soupramanien Sivagnanam sivas@ Published online 23 December 2002 Critical Care 2003 7 119-120 DOI cc1871 This article is online at http content 7 2 119 2003 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Vancomycin can cause two types of hypersensitivity reactions the red man syndrome and anaphylaxis. Red man syndrome has often been associated with rapid infusion of the first dose of the drug and was initially attributed to impurities found in vancomycin preparations. Even after improvement in vancomycin s purity however reports of the syndrome persist. Other antibiotics . ciprofloxacin amphotericin B rifampicin and teicoplanin or other drugs that stimulate histamine release can result in red man syndrome. Discontinuation of the vancomycin infusion and administration of diphenhydramine can abort most of the reactions. Slow intravenous administration of vancomycin should minimize the risk of infusion-related adverse effects. Keywords antibiotics antihistamines red man syndrome vancomycin The incidence of nosocomial infections in hospitalized patients varies between 5 and 15 1 . Nosocomial infection can lead to complications in 25-33 of those patients admitted to intensive care units. Vancomycin is often used in intensive care units. It is the drug of choice for the treatment of infections due to methicillin-resistant staphylococci Corynebacterium jeikeium and resistant strains of Streptococcus pneumoniae. Vancomycin is an alternative drug for serious staphylococcal and streptococcal infections including endocarditis when allergy precludes the .

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