tailieunhanh - Báo cáo hóa học: " The dynamics underlying pseudo-plateau bursting in a pituitary cell model"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : The dynamics underlying pseudo-plateau bursting in a pituitary cell model | Journal of Mathematical Neuroscience 2011 1 12 0 The Journal of Mathematical Neuroscience DOI 2190-8567-1-12 RESEARCH Open Access The dynamics underlying pseudo-plateau bursting in a pituitary cell model Wondimu Teka Joel Tabak Theodore Vo Martin Wechselberger Richard Bertram Received 27 June 2011 Accepted 8 November 2011 Published online 8 November 2011 2011 Teka et al. licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License Abstract Pituitary cells of the anterior pituitary gland secrete hormones in response to patterns of electrical activity. Several types of pituitary cells produce short bursts of electrical activity which are more effective than single spikes in evoking hormone release. These bursts called pseudo-plateau bursts are unlike bursts studied mathematically in neurons plateau bursting and the standard fast-slow analysis used for plateau bursting is of limited use. Using an alternative fast-slow analysis with one fast and two slow variables we show that pseudo-plateau bursting is a canard-induced mixed mode oscillation. Using this technique it is possible to determine the region of parameter space where bursting occurs as well as salient properties of the burst such as the number of spikes in the burst. The information gained from this one-fast two-slow decomposition complements the information obtained from a two-fast one-slow decomposition. WTeka Department of Mathematics Florida State University Tallahassee FL32306 USA e-mail wteka@ J Tabak Department of Biological Science Florida State University Tallahassee FL 32306 USA e-mail joel@ T Vo M Wechselberger School of Mathematics and Statistics University of Sydney Sydney NSW 2006 Australia TVo e-mail thvo4579@ M Wechselberger e-mail wm@ R Bertram El Department of Mathematics and Programs in Neuroscience and Molecular Biophysics Florida State University Tallahassee FL .

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