tailieunhanh - Báo cáo hóa học: " The effect of red blood cell transfusion on tissue oxygenation and microcirculation in severe septic patients"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : The effect of red blood cell transfusion on tissue oxygenation and microcirculation in severe septic patients | Sadaka et al. Annals of Intensive Care 2011 1 46 http content 1 1 46 Ù Annals of Intensive Care a SpringerOpen Journal RESEARCH Open Access The effect of red blood cell transfusion on tissue oxygenation and microcirculation in severe septic patients Farid Sadaka Ravi Aggu-Sher Katie Krause Jacklyn O Brien Eric S Armbrecht and Robert W Taylor Abstract Background Microcirculation plays a vital role in the development of multiple organ failure in severe sepsis. The effects of red blood cell RBC transfusions on these tissue oxygenation and microcirculation variables in early severe sepsis are not well defined. Methods This is a prospective observational study of patients with severe sepsis requiring RBC transfusions of one to two units of non-leukoreduced RBCs for a hemoglobin or for a hemoglobin between and with lactic acidosis or central venous oxygen saturation 70 . This study took place in a 54-bed medical-surgical intensive care unit of a university-affiliated hospital. Thenar tissue oxygen saturation was measured by using a tissue spectrometer on 21 patients and a vaso-occlusive test was performed before and 1 hour after transfusion. The sublingual microcirculation was assessed with a Sidestream Dark Field device concomitantly on 11 of them. Results RBC transfusion resulted in increase in hemoglobin to g dl p . RBC transfusion did not globally affect near-infrared spectrometry NIRS -derived variables. However percent change in muscle oxygen consumption was negatively correlated with baseline r - p . There was no statistically significant correlation between percent change in vascular reactivity and baseline p . There was a positive correlation between percent change in oxygen consumption and percent change in vascular reactivity r p . In the 11 patients RBC transfusion did not globally affect NIRS-derived variables or SDF-derived variables. There was no statistically