tailieunhanh - Báo cáo khoa hoc:" Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression | Journal of Negative Results in BioMedicine BioMed Central Research Open Access Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression Javier Cotignola1 Pampa Roy1 Ami Patel2 Nicole Ishill1 Shivang Shah1 Alan Houghton2 Daniel Coit3 Allan Halpern2 Klaus Busam4 Marianne Berwick5 and Irene Orlow 1 Address Epidemiology and Biostatistics Memorial Sloan-Kettering Cancer Center New York NY USA 2Department of Medicine Memorial Sloan-Kettering Cancer Center New York NY USA 3Department of Surgery Memorial Sloan-Kettering Cancer Center New York NY USA 4Pathology Department Memorial Sloan-Kettering Cancer Center New York NY USA and 5Division of Epidemiology University of New Mexico Albuquerque NM USA Email Javier Cotignola - javiercoty@ Pampa Roy - royp@ Ami Patel - amip74@ Nicole Ishill - ishilln@ Shivang Shah - Alan Houghton - houghtoa@ Daniel Coit - coitd@ Allan Halpern - halperna@ Klaus Busam - busamk@ Marianne Berwick - MBerwick@ Irene Orlow - orlowi@ Corresponding author Published 24 October 2007 Received 5 January 2007 Journal of Negative Results in BioMedicine 2007 6 9 doi 186 1477-5751-6-9 Accepted 24 October 2007 This article is available from http content 6 1 9 2007 Cotignola et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The matrix metalloproteinases MMPs are enzymes that cleave various components of the extracellular matrix ECM and basement membranes. MMPs are expressed in melanocytes and their overexpression has been linked to tumor development progression and metastasis. At the genetic level the following .