tailieunhanh - Báo cáo y học: "Science review: Apoptosis in acute lung injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Science review: Apoptosis in acute lung injury. | Available online http content 7 5 355 Review Science review Apoptosis in acute lung injury Gustavo Matute-Bello1 and Thomas R Martin2 Acting Assistant Professor Medical Research Service of the Veterans Affairs Puget Sound Health Care System and the Division of Pulmonary and Critical Care Medicine Department of Medicine University of Washington School of Medicine Seattle Washington USA 2Professor Medical Research Service of the Veterans Affairs Puget Sound Health Care System and the Division of Pulmonary and Critical Care Medicine Department of Medicine University of Washington School of Medicine Seattle Washington USA Correspondence Thomas R Martin trmartin@ Published online 4 April 2003 Critical Care 2003 7 355-358 DOI cc1861 This article is online at http content 7 5 355 2003 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Apoptosis is a process of controlled cellular death whereby the activation of specific death-signaling pathways leads to deletion of cells from tissue. The importance of apoptosis resides in the fact that several steps involved in the modulation of apoptosis are susceptible to therapeutic intervention. In the present review we examine two important hypotheses that link apoptosis with the pathogenesis of acute lung injury in humans. The first of these namely the neutrophilic hypothesis suggests that during acute inflammation the cytokines granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor prolong the survival of neutrophils and thus enhance neutrophilic inflammation. The second hypothesis the epithelial hypothesis suggests that epithelial injury in acute lung injury is associated with apoptotic death of alveolar epithelial cells triggered by soluble mediators such as soluble Fas ligand. We also review recent studies that suggest that the rate of clearance of apoptotic neutrophils may be associated with resolution of neutrophilic .