tailieunhanh - Báo cáo y học: "Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance. | Available online http content 7 4 291 Review Science review Cell membrane expression connectivity regulates neutrophil delivery function and clearance Andrew JE Seely1 José L Pascual2 and Nicolas V Christou3 1 Resident Divisions of Thoracic Surgery and Critical Care Medicine University of Ottawa Ottawa Ontario Canada 2Resident Division of General Surgery McGill University Health Center Montreal Quebec Canada 3Professor and Chief Division of General Surgery McGill University Health Center Montreal Quebec Canada Correspondence Andrew JE Seely Published online 9 January 2003 Critical Care 2003 7 291-307 DOI cc1853 This article is online at http content 7 4 291 2003 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract As the principal cellular component of the inflammatory host defense and contributor to host injury after severe physiologic insult the neutrophil is inherently coupled to patient outcome in both health and disease. Extensive research has focused on the mechanisms that regulate neutrophil delivery function and clearance from the inflammatory microenvironment. The neutrophil cell membrane mediates the interaction of the neutrophil with the extracellular environment it expresses a complex array of adhesion molecules and receptors for various ligands including mediators cytokines immunoglobulins and membrane molecules on other cells. This article presents a review and analysis of the evidence that the neutrophil membrane plays a central role in regulating neutrophil delivery production rolling adhesion diapedesis and chemotaxis function priming and activation microbicidal activity and neutrophil-mediated host injury and clearance apoptosis and necrosis . In addition we review how change in neutrophil membrane expression is synonymous with change in neutrophil function in vivo. Employing a complementary analysis of the neutrophil as a complex system neutrophil membrane expression may