tailieunhanh - Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology. | Available online http content 7 6 427 Review Science Review Vasopressin and the cardiovascular system part 1 - receptor physiology Cheryl L Holmes1 Donald W Landry2 and John T Granton3 1Staff intensivist Department of Medicine Division of Critical Care Kelowna General Hospital Kelowna BC Canada 2Associate Professor Department of Medicine Columbia University New York New York USA 3Assistant Professor of Medicine Faculty of Medicine and Program Director Critical Care Medicine University of Toronto and Consultant in Pulmonary and Critical Care Medicine Director Pulmonary Hypertension Program University Health Network Toronto Ontario Canada Corresponding author John T Granton Published online 26 June 2003 Critical Care 2003 7 427-434 DOI cc2337 This article is online at http content 7 6 427 2003 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Vasopressin is emerging as a rational therapy for vasodilatory shock states. Unlike other vasoconstrictor agents vasopressin also has vasodilatory properties. The goal of the present review is to explore the vascular actions of vasopressin. In part 1 of the review we discuss structure signaling pathways and tissue distributions of the classic vasopressin receptors namely V1 vascular V2 renal V3 pituitary and oxytocin receptors and the P2 class of purinoreceptors. Knowledge of the function and distribution of vasopressin receptors is key to understanding the seemingly contradictory actions of vasopressin on the vascular system. In part 2 of the review we discuss the effects of vasopressin on vascular smooth muscle and the heart and we summarize clinical studies of vasopressin in shock states. Keywords adrenergic agents antidiurectic hormone cardiac inotropy hypotension nitric oxide oxytocin physiology potassium channels receptors septic shock smooth muscle vasoconstriction vascular vasodilation vasopressin Introduction Arginine vasopressin hereafter .

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