tailieunhanh - Báo cáo y học: "The limitations of observational studies on the treatment of severe sepsis — authors’ response"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: The limitations of observational studies on the treatment of severe sepsis — authors’ response. | Critical Care December 2002 Vol 6 No 6 Messori et al. Letter The limitations of observational studies on the treatment of severe sepsis - authors response Andrea Messori1 Franca Vacca2 Monica Vaiani2 and Sabrina Trippoli2 Coordinator Laboratorio SIFO di Farmacoeconomia c o Drug Information Center Azienda Ospedaliera Careggi Florence Italy 2Researcher Laboratorio SIFO di Farmacoeconomia c o Drug Information Center Azienda Ospedaliera Careggi Florence Italy Correspondence Andrea Messori md3439@ Published online 31 October 2002 Critical Care 2002 6 548 DOI cc1841 This article is online at http content 6 6 548 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X The observations by Wiederman 1 on our recently published paper 2 raise some confusion between facts and opinions . In the area of the treatment of sepsis with antithrombin III the results of our observational study are facts and are therefore a contribution to a better knowledge of this therapeutic problem. While previous evidence was based only on randomised controlled trials RCTs our study has provided some additional evidence using an observational design. Nobody can deny that having data from both RCTs and observational studies is better than having data from only RCTs. The interpretation of our results opinions is another issue. It is well known that the value of observational studies is a matter of debate 3-5 and of course our study does not make an exception. We think however that one cannot always restart from the beginning the debate on the usefulness of observational studies every time one such study is published. The same considerations apply to meta-analysis. Detractors of meta-analysis may argue that there has been a spectacular failure . to predict the outcomes of subsequent large scale RCTs . Many other researchers have a different and more favourable view. In any case numerous metaanalyses continue to be published in authoritative journals in 2001 152

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
TÀI LIỆU MỚI ĐĂNG
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.