tailieunhanh - Báo cáo y học: Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α. | Available online http content 7 1 47 Review Science review Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury role for hypoxia-inducible factor-1 a John J Haddad Severinghaus-Radiometer Research Laboratories Molecular Neuroscience Research Division Department of Anesthesia and Perioperative Care University of California at San Francisco School of Medicine San Francisco California USA Correspondence John J Haddad haddadj@ Published online 14 October 2002 Critical Care 2003 7 47-54 DOI cc1840 This article is online at http content 7 1 47 2003 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract A progressive rise of oxidative stress due to altered reduction-oxidation redox homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription in physiology and pathophysiology. Reactive oxygen species and reactive nitrogen species serve as signaling messengers for the evolution and perpetuation of the inflammatory process that is often associated with the condition of oxidative stress which involves genetic regulation. Changes in the pattern of gene expression through reactive oxygen species reactive nitrogen species-sensitive regulatory transcription factors are crucial components of the machinery that determines cellular responses to oxidative redox conditions. The present review describes the basic components of the intracellular oxidative redox control machinery and its crucial regulation of oxygen-sensitive and redox-sensitive transcription factors within the context of lung injury. Particularly the review discusses mechanical ventilation and NF-kB-mediated lung injury ischemia-reperfusion and transplantation compromised host defense and inflammatory stimuli and hypoxemia and the crucial role of hypoxia-inducible factor in mediating lung injury. Changes in the pattern of gene expression through regulatory transcription .