tailieunhanh - Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κB. | Available online http content 6 6 481 Review Science review Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury role for nuclear factor-KB John J Haddad Severinghaus-Radiometer Research Laboratories Molecular Neuroscience Research Division Department of Anesthesia and Perioperative Care University of California at San Francisco School of Medicine San Francisco California USA Correspondence John J Haddad haddadj@ Published online 14 October 2002 Critical Care 2002 6 481-490 DOI cc1839 This article is online at http content 6 6 481 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract The primary role of pulmonary airways is to conduct air to the alveolar epithelium where gas exchange can efficiently occur. Injuries to airways resulting from inhalation of airborne pollutants and parenteral exposure to ingested pollutants that cause oxidative stress have the potential to interfere with this process. A progressive rise of oxidative stress due to altered reduction-oxidation redox homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription in lung physiology and pathophysiology. Reactive metabolites serve as signaling messengers for the evolution and perpetuation of the inflammatory process that is often associated with cell death and degeneration. Redox-sensitive transcription factors are often associated with the development and progression of many human disease states and inflammatory-related injury particularly of the lung. The present review elaborates on the role of the redox-sensitive and oxygen-sensitive transcription factor NF-kB in mediating lung injury. Changes in the pattern of gene expression through regulatory transcription factors are crucial components of the machinery that determines cellular responses to oxidative and redox perturbations. Additionally the discussion of the possible therapeutic .