tailieunhanh - Báo cáo khoa hoc:" Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis | Journal of Negative Results in BioMedicine BioMed Central Brief report Open Access Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis I Manna1 P Valentino2 A La Russa1 F Condino1 RNisticò2 M Liguori1 A Clodomiro2 V Andreoli1 D Pirritano2 R Cittadella1 and A Quattrone 1 2 Address 1Institute of Neurological Science National Research Council Cosenza Italy and 2Department of Medical Sciences Institute of Neurology University Magna Graecia Catanzaro Italy Email I Manna - P Valentino - A La Russa - F Condino - RNisticò - M Liguori - A Clodomiro - V Andreoli - D Pirritano - R Cittadella - A Quattrone - Corresponding author Published 27 February 2006 Received 10 November 2005 r r-7ri r Accepted 27 February 2006 Journal of Negative Results in BioMedicine2006 5 3 doi 186 1477-5751-5-3 This article is available from http content 5 1 3 2006Manna et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract There is evidence that multiple sclerosis MS may associated with cognitive impairment in 25 to 40 of cases. The gene encoding myeloperoxidase MPO is involved in molecular pathways leading to P-amyloid deposition. We investigated a functional biallelic G A polymorphism in the promoter region -463 of the MPO gene in 465 patients affected by MS divided into 204 cognitively normal and 261 impaired. We did not find significant differences in allele or genotype distributions between impaired and preserved MS patients. Our findings suggest .