tailieunhanh - Báo cáo y học: " Clinical review: Immunodepression in the surgical patient and increased susceptibility to infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Clinical review: Immunodepression in the surgical patient and increased susceptibility to infection. | Critical Care August 2002 Vol 6 No 4 Angele and Faist Review Clinical review Immunodepression in the surgical patient and increased susceptibility to infection Martin K Angele and Eugen Faist Department of Surgery Klinikum Grosshadern Ludwig-Maximilians University Munich Germany Correspondence Eugen Faist faist@ Published online 24 May 2002 Critical Care 2002 6 298-305 This article is online at http content 6 4 298 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Several studies indicate that organ failure is the leading cause of death in surgical patients. An excessive inflammatory response followed by a dramatic paralysis of cell-mediated immunity following major surgery appears to be responsible for the increased susceptibility to subsequent sepsis. In view of this most of the scientific and medical research has been directed towards measuring the progression and inter-relationship of mediators following major surgery. Furthermore the effect of those mediators on cell-mediated immune responses has been studied. This article will focus on the effect of blood loss and surgical injury on cell-mediated immune responses in experimental studies utilizing models of trauma and hemorrhagic shock which have defined effects on the immunoinflammatory response. Subsequently these findings will be correlated with data generated from surgical patients. The results of these studies may generate new approaches for the treatment of immunodepression following major surgery thus reducing the susceptibility to infection and increasing the survival rate of the critical ill surgical patient. Keywords immunodepression infection surgery Several studies indicate that organ failure is the leading cause of death in surgical patients 1 . Most cases of multiple organ dysfunction are precipitated by infection. Nonetheless the outcome of organ dysfunction does not correlate well with the microbiology of multiple organ dysfunction .