tailieunhanh - Báo cáo y học: "Looking beyond 28-day all-cause mortality"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Looking beyond 28-day all-cause mortality. | Available online http content 6 4 293 Commentary Looking beyond 28-day all-cause mortality Gordon Rubenfeld Assistant Professor Department of Medicine University of Washington Seattle Washington USA Correspondence Gordon Rubenfeld nodrog@ Published online 8 July 2002 Critical Care 2002 6 293-294 This article is online at http content 6 4 293 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract A growing body of evidence indicates that survivors of intensive care have an impaired quality of life. It is not entirely clear from the available literature whether this impairment is a complication of critical illness or a complication of therapy. There is little evidence to guide physicians to treatments in the intensive care unit that will minimize the effects of critical illness on these sequelae. Although the study by Rublee and colleagues in this issue of Critical Care provides little clinically useful information about the effects of antithrombin III on quality of life it provides some insight into the challenges that investigators will encounter as we try to incorporate these outcomes into studies of critical illness. Keywords outcomes research quality of life sepsis In this issue of Critical Care Dale Rublee and colleagues look beyond 28-day all-cause mortality assessing the effects of antithrombin III on quality of life in sepsis survivors 1 . Although many of us would like to think that the battle has been won when a patient leaves the intensive care unit ICU after severe sepsis or acute respiratory distress syndrome ARDS a growing body of literature indicates that survivors of intensive care have an increased risk of death and have a significantly impaired quality of life after they leave the ICU. There are several possible mechanisms for these long-term effects and many patients may be affected by several of them. Survival may be impaired simply because people with severe co-morbid diseases are most