tailieunhanh - Báo cáo y học: "Lactate: a key metabolite in the intercellular metabolic interplay"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Lactate: a key metabolite in the intercellular metabolic interplay. | Critical Care August 2002 Vol 6 No 4 Leverve and Mustafa Commentary Lactate a key metabolite in the intercellular metabolic interplay Xavier M Leverve1 and Iqbal Mustafa1 2 1 Laboratoire de Bioénergétique Fondamentale et Appliquée INSERM E0221 Université Joseph Fourier Grenoble France intensive Care Unit Harapan Kita National Cardiovascular Center Jakarta Indonesia Correspondence Xavier Leverve Published online 8 July 2002 Critical Care 2002 6 284-285 This article is online at http content 6 4 284 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Most physicians involved in intensive care consider lactate solely as a deleterious metabolite responsible for high morbidity and bad prognosis in severe patients. For the physiologist however lactate is a key metabolite alternatively produced or consumed. Many studies in the literature have infused animals or humans with exogenous lactate demonstrating its safety and usefulness but the bad reputation of lactate is still widespread. The metabolic meaning of glucose-lactate cycling exceeds its initial role described by Cori and Cori. According to recent works concerning lactate it can be predicted that a new role as a therapeutic agent will arise for this metabolite. Keywords brain Cori cycle exogenous substrate kidney lung metabolic shuttle A satellite meeting on lactate was organized during the 8th International Symposium on Shock and Critical Care August 2001 Bali Indonesia. The aim of the symposium was to highlight lactate from a different standpoint to the classical view of being a prognosis marker often solely considered by many physicians involved in intensive care medicine. The review papers on lactate in the present issue discuss four of the lectures presented in this symposium by Cano 1 Bellomo 2 Iscra et al. 3 and Schurr 4 . Lactic acid which is mostly present in biological fluids as its dissociated cationic form lactate- is widely distributed .

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