tailieunhanh - Báo cáo y học: "Potential therapeutic agents in the management of organophosphorus poisoning Soupramanien Sivagnanam"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Potential therapeutic agents in the management of organophosphorus poisoning Soupramanien Sivagnanam. | Critical Care June 2002 Vol 6 No 3 Sivagnanam Letter Potential therapeutic agents in the management of organophosphorus poisoning Soupramanien Sivagnanam Senior Registrar Department of Anaesthesia and Intensive Care Sultan Qaboos University Hospital Al Khod Muscat Oman Correspondence Soupramanien Sivagnanam sivas@ Published online 18 April 2002 Critical Care 2002 6 260-261 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X This letter is a response to the report by Sungur and Guven 1 on intensive care management of organophosphate insecticide poisoning which was recently published in Critical Care. Insect damage costs the world loses approximately 6 billion pounds sterling every year. Use of pesticides has increased food production in parallel with population growth in many parts of the world. Many insect-borne diseases have been eliminated or controlled by the use of insecticides. Organophosphorus compounds are widely used as insecticides and as agents of chemical warfare. According to the World Health Organization 2 1 million serious accidental and 2 million suicidal poisonings with insecticides occur worldwide every year and of these approximately 200 000 die mostly in developing countries. Atropine and oximes are traditionally used in the management of such poisonings but they have failed to reduce the attendant mortality and morbidity. Some agents have been found to reduce the toxicity of organophosphorus compounds in animal experiments and they have potential as therapeutic agents in the management of organophosphorus poisoning. These agents are magnesium clonidine and fluoride. Kiss and Fazekas 3 reported control of premature ventricular contractions with intravenous magnesium. Magnesium was considered to counteract the direct toxic inhibitory action of organophosphorus compounds on sodium-potassium ATPase. It also inhibits acetylcholine release 4 . Singh and coworkers 5 found that intravenous magnesium reversed the .