tailieunhanh - Báo cáo y học: "Severe reperfusion lung injury after double lung transplantation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Severe reperfusion lung injury after double lung transplantation. | Critical Care June 2002 Vol 6 No 3 Della Rocca et al. Research Severe reperfusion lung injury after double lung transplantation Giorgio Della Rocca1 Federico Pierconti2 Maria Gabriella Costa2 Cecilia Coccia2 Livia Pompei2 Monica Rocco1 Federico Venuta3 and Paolo Pietropaoli4 Associate Professor Istituto di Anestesiologia e Rianimazione University of Rome La Sapienza Rome Italy 2Assistant Istituto di Anestesiologia e Rianimazione University of Rome La Sapienza Rome Italy 3Associate Professor Cattedra di Chirurgia Toracica University of Rome La Sapienza Rome Italy 4Director of Department Istituto di Anestesiologia e Rianimazione University of Rome La Sapienza Rome Italy Correspondence Giorgio Della Rocca Received 15 November 2001 Revisions requested 14 January 2002 Revisions received 21 February 2002 Accepted 7 March 2002 Published 1 May 2002 Critical Care 2002 6 240-244 2002 Della Rocca et al. licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Aim To demonstrate the effects of combined inhaled nitric oxide and surfactant replacement as treatment for acute respiratory distress syndrome. This treatment has not previously been documented for reperfusion injury after double lung transplantation. Method A 24-year-old female with cystic fibrosis underwent double lung transplantation. During implantation of the second lung a marked increase in pulmonary artery pressure associated with systemic hypotension hypoxemia and low cardiac output were observed. Notwithstanding the patient received support from cardiovascular drugs and pulmonary vasodilators cardiopulmonary by-pass was necessary. In the intensive care unit the patient received the same drug support inhaled nitric oxide and two bronchoscopic applications of bovine surfactant. Results A rapid improvement in PaO2 FiO2 within 2-3 hours of administration of surfactant was seen. The patient is well at follow-up 1 year post-transplant. Conclusion There is a .