tailieunhanh - Báo cáo y học: " Asthma and COPD in cystic fibrosis intron-8 5T carriers. A population-based study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Asthma and COPD in cystic fibrosis intron-8 5T carriers. A population-based study. | Respiratory Research BioMed Central Research Open Access Asthma and COPD in cystic fibrosis intron-8 5T carriers. A population-based study Morten Dahl1 Anne Tybj rg-Hansen2 4 Peter Lange3 4 and Borge G Nordestgaard 1 4 Address Department of Clinical Biochemistry Herlev University Hospital DK-2730 Herlev Denmark 2Department of Clinical Biochemistry Rigshospitalet Copenhagen University Hospital DK-2100 Copenhagen 0 Denmark 3Department of Respiratory Medicine Hvidovre University Hospital DK-2650 Hvidovre Denmark and 4The Copenhagen City Heart Study Bispebjerg University Hospital DK-2200 Copenhagen N Denmark Email Morten Dahl - dahlos2003@ Anne Tybj rg-Hansen - at-h@ Peter Lange - Borge G Nordestgaard - brno@ Corresponding author Published 09 October 2005 Received 17 April 2005 Respiratory Research 2005 6 113 doi 1465-9921-6-113 Accepted 09 October 2005 This article is available from http content 6 1 1 13 2005 Dahl et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Carriers of cystic fibrosis intron-8 5T alleles with high exon-9 skipping could have increased annual lung function decline and increased risk for asthma or chronic obstructive pulmonary disease COPD . Methods We genotyped 9131 individuals from the adult Danish population for cystic fibrosis 5T 7T 9T and F508del alleles and examined associations between 1 1 different genotype combinations and annual FEV1 decline and risk of asthma or COPD. Results 5T heterozygotes vs. 7T homozygous controls had no increase in annual FEV1 decline self-reported asthma spirometry-defined COPD or incidence of hospitalization from asthma or COPD. In 5T 7T heterozygotes vs. 7T .