tailieunhanh - Báo cáo y học: "Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatic. | Respiratory Research BioMed Central Research Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics Kawa Amin1 Christer Janson2 Lahja Sevéus1 Kaoru Miyazaki3 Ismo Virtanen4 and Per Venge 1 Open Access Address Department of Medical Sciences Clinical Chemistry Uppsala University Uppsala Sweden 2Department of Medical Sciences Respiratory Medicine and Allergology Uppsala University Uppsala Sweden 3Division of Cell Biology Kihara Institute for Biological Research Yokohama City University Yokohama Japan and 4Institute of Biomedicine Anatomy University of Helsinki Helsinki Finland Email Kawa Amin - Christer Janson - Lahja Sevéus - lahja@ Kaoru Miyazaki - miyazaki@ Ismo Virtanen - PerVenge - Corresponding author Published 22 September 2005 Received 09 February 2005 Respiratory Research 2005 6 110 doi 1465-9921-6-110 Accepted 22 September 2005 This article is available from http content 6 1 1 10 2005 Amin et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Laminins are a group of proteins largely responsible for the anchorage of cells to basement membranes. We hypothesized that altered Laminin chain production in the bronchial mucosa might explain the phenomenon of epithelial cell shedding in asthma. The aim was to characterize the presence of Laminin chains in the SEBM and epithelium in allergic and non-allergic asthmatics. Patients and methods Biopsies were taken from the bronchi of 11 patients with allergic and 9 patients with non-allergic asthma and from 7 controls and stained with antibodies against the Laminin ln