tailieunhanh - Báo cáo y học: "Chlamydophila pneumoniae induces expression of Toll-like Receptor 4 and release of TNF-α and MIP-2 via an NF-κB pathway in rat type II pneumocytes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Chlamydophila pneumoniae induces expression of Toll-like Receptor 4 and release of TNF-α and MIP-2 via an NF-κB pathway in rat type II pneumocytes. | BioMed Central Respiratory Research Research Open Access Chlamydophila pneumoniae induces expression of Toll-like Receptor 4 and release of TNF-a and MIP-2 via an NF-kB pathway in rat type II pneumocytes Heide Wissel 1 Christian Schulz1 Petra Koehne2 Ekkehard Richter3 Matthias Maass4 and Mario Rudiger1 5 Address 1Clinic for Neonatology Campus Charité Mitte Schumannstr. 20-21 D-10098 Berlin Germany 2Clinic for Neonatology Campus Charité Virchow-Klinikum Berlin Germany 3Department of Cell Biology Institute of Biology Humboldt-University Berlin Germany 4SALK Microbiology Salzburger Landeskliniken Muellner-Hauptstr. 56 A-5020 Salzburg Austria and 5Clinic for Neonatology Medical University Innsbruck Austria Email Heide Wissel - hwissel@ Christian Schulz - lonyx@ Petra Koehne - Ekkehard Richter - Matthias Maass - Mario Rudiger - Corresponding author Published 03 June 2005 Received 05 April 2005 Respiratory Research 2005 6 51 doi 1465-9921 -6-51 Accepted 03 June 2005 This article is available from http content 6 1 51 2005 Wissel et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The role of alveolar type II cells in the regulation of innate and adaptive immunity is unclear. Toll-like receptors TLRs have been implicated in host defense. The purpose of the present study was to investigate whether Chlamydophila pneumoniae I alters the expression of TLR2 and orTLR4 in type II cells in a II Rho-GTPase- and III NF-KB-dependent pathway subsequently IV leading to the production of IV pro-inflammatory TNF-a and MIP-2. Methods Isolated rat type II pneumocytes were .