tailieunhanh - Báo cáo y học: "The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases. | Respiratory Research BioMed Central Review Open Access The pathophysiological function of peroxisome proliferator-activated receptor-Y in lung-related diseases Tom Hsun-Wei Huangt Valentina Razmovski-Naumovskik Bhavani Prasad Kota Diana Shu-Hsuan Lin and Basil D Roufogalis Address Faculty of Pharmacy A15 University of Sydney New South Wales 2006 Australia Email Tom Hsun-Wei Huang - tomh@ Valentina Razmovski-Naumovski - tinar@ Bhavani Prasad Kota - bkot2010@ Diana Shu-Hsuan Lin - dlin4513@ Basil D Roufogalis - basilr@ Corresponding author fEqual contributors Published 09 September 2005 Respiratory Research 2005 6 102 doi 1465-9921-6-102 Received 17 January 2005 Accepted 09 September 2005 This article is available from http content 6 1 102 2005 Huang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Research into respiratory diseases has reached a critical stage and the introduction of novel therapies is essential in combating these debilitating conditions. With the discovery of the peroxisome proliferator-activated receptor and its involvement in inflammatory responses of cardiovascular disease and diabetes attention has turned to lung diseases and whether knowledge of this receptor can be applied to therapy of the human airways. In this article we explore the prospect of peroxisome proliferator-activated receptor-Y as a marker and treatment focal point of lung diseases such as asthma chronic obstructive pulmonary disorder lung cancer and cystic fibrosis. It is anticipated that peroxisome proliferator-activated receptor-Y ligands will provide not only useful mechanistic pathway information but also