tailieunhanh - Báo cáo khoa học: "Effect of tylosin on dogs with suspected tylosin-responsive diarrhea: a placebo-controlled, randomized, double-blinded, prospective clinical trial"

Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú yđề tài: Effect of tylosin on dogs with suspected tylosin-responsive diarrhea: a placebo-controlled, randomized, double-blinded, prospective clinical trial. | Kilpinen et al. Acta Veterinaria Scandinavica 2011 53 26 http content 53 1 26 AVS ACTAVETERINARIA teJnoZ 10 SCANDINAVICA RESEARCH Open Access Effect of tylosin on dogs with suspected tylosin-responsive diarrhea a placebo-controlled randomized double-blinded prospective clinical trial 1 12 3 1 Susanne Kilpinen Thomas Spillmann Pernilla Syrja Teresa Skrzypczak Maria Louhelainen and Elias Westermarck1 Abstract Background The macrolid antibiotic tylosin has been widely used to treat canine chronic diarrhea although its efficacy is based on anecdotal reports and experimental studies in dogs and not on strong scientific evidence. The term tylosin-responsive diarrhea TRD refers to diarrheal disorders responding to tylosin therapy within a few days. In TRD the stool remains normal as long as tylosin treatment continues but diarrhea reappears in many dogs within weeks after discontinuation. The aim of our trial was to assess the effect of tylosin on fecal consistency compared with a placebo treatment in dogs with suspected TRD and additionally to establish whether tylosin in dogs with recurrent diarrhea is as effective as empirical studies and anecdotal reports suggest. Methods Subjects comprised 71 client-owned dogs that according to the owners had previously been treated successfully with tylosin due to recurrent diarrhea of unknown etiology. At the initial examination where there were no signs of diarrhea the dogs were randomly assigned in a 2 1 ratio to a tylosin or placebo group. During a two-month follow-up the owners evaluated the fecal consistency according to previously published guidelines. When diarrhea recurred either tylosin 25 mg kg q 24 h 7 days or placebo treatment was initiated orally. Treatment outcome was evaluated as the mean of fecal consistency scores assigned during the last three days of the treatment period. To test for differences between the tylosin and placebo group in the proportion of responders Pearson s Chi-squared test .