tailieunhanh - Báo cáo y học: "Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust. | Respiratory Research BioMed Central Research Open Access Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust Stefan Ivanov 1 Lena Palmberg2 Per Venge3 Kjell Larsson2 and Anders Lindén1 Address 1Lung Pharmacology Group Department of Respiratory Medicine and Allergy Institute for Internal Medicine Gõteborg University Guldhedsgatan 10A 413 46 Gothenburg Sweden 2Lung and Allergy Research the Institute of Environmental Medicine Karolinska Institute 171 77 Stockholm Sweden and 3Department of Clinical Chemistry and Pharmacology Uppsala University 751 85 Uppsala Sweden Email Stefan Ivanov - Lena Palmberg - Per Venge - Kjell Larsson - Anders Lindén - Corresponding author Published 25 May 2005 Received 08 November 2004 Respiratory Research 2005 6 44 doi 1465-9921 -6-44 Accepted 25 May 2005 This article is available from http content 6 1 44 2005 Ivanov et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In mice the cytokine interleukin IL -17A causes a local accumulation of neutrophils within the bronchoalveolar space. IL-17A may thereby also contribute to an increased local proteolytic burden. In the current study we determined whether mRNA for IL-17A is elevated and protein expression of IL-17A occurs locally in inflammatory cells within the human bronchoalveolar space during severe inflammation caused by organic dust. We also assessed the expression of the elastinolytic protease MMP-9 in this airway compartment. Methods Six healthy non-smoking human volunteers were exposed to .