tailieunhanh - Báo cáo y học: "Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers. | Respiratory Research BioMed Central Research Open Access Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers Brigitte WM Willemse1 2 Nick HT ten Hacken2 Bea Rutgers1 Dirkje S Postma2 and Wim Timens 1 Address Department of Pathology University Medical Centre Groningen Groningen The Netherlands and 2Department of Pulmonology University Medical Centre Groningen Groningen The Netherlands Email Brigitte WM Willemse - Nick HT ten Hacken - Bea Rutgers - Dirkje S Postma - WimTimens - Corresponding author Published 25 April 2005 Received 14 November 2004 Respiratory Research 2005 6 38 doi 1465-9921 -6-38 Accepted 25 April 2005 This article is available from http content 6 1 38 2005 Willemse et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Inflammation in the airways and lung parenchyma underlies fixed airway obstruction in chronic obstructive pulmonary disease. The exact role of smoking as promoting factor of inflammation in chronic obstructive pulmonary disease is not clear partly because studies often do not distinguish between current and ex-smokers. Methods We investigated airway inflammation in sputum and bronchial biopsies of 34 smokers with chronic obstructive pulmonary disease 9 Global initiative for Chronic Obstructive Lung Disease stage 0 9 stage I 10 stage II and 6 stage III and 26 asymptomatic smokers and its relationship with past and present smoking habits and airway obstruction. Results Neutrophil percentage interleukin-8 and eosinophilic-cationic-protein levels in .