tailieunhanh - Báo cáo y học: " Airway allergen exposure stimulates bone marrow eosinophilia partly via IL-9"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Airway allergen exposure stimulates bone marrow eosinophilia partly via IL-9. | Respiratory Research BioMed Central Research Open Access Airway allergen exposure stimulates bone marrow eosinophilia partly via IL-9 Brigita Sitkauskiene1 2 3 Madeleine Râdinger1 Apostolos Bossios1 Anna-Karin Johansson1 Raimundas Sakalauskas2 and Jan Lotvall 1 Address 1Frhe Lung Pharmacology Group Department of Respiratory Medicine and Allergology Institute of Internal Medicine Goteborg University Guldhedsgatan 10A 413 46 Gothenburg Sweden 2Department of Pulmonology and Immunology Kaunas University of Medicine Eiveniu 2 50009 Kaunas Lithuania and 3Lab of Pulmonology Institute for Biomedical Research Kaunas University of Medicine Eiveniu 4 50009 Kaunas Lithuania Email Brigita Sitkauskiene - Madeleine Râdinger - Apostolos Bossios - Anna-Karin Johansson - Raimundas Sakalauskas - raisak@ Jan Lotvall - Corresponding author Published II April 2005 Received 25 November 2004 Respiratory Research 2005 6 33 doi 1465-9921-6-33 Accepted 11 April 2005 This article is available from http content 6 I 33 2005 Sitkauskiene et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Interleukin IL -9 is a Th2-derived cytokine with pleiotropic biological effects which recently has been proposed as a candidate gene for asthma and allergy. We aimed to evaluate the therapeutic effect of a neutralizing anti-IL-9 antibody in a mouse model of airway eosinophilic inflammation and compared any such effect with anti-IL-5 treatment. Methods OVA-sensitized Balb c mice were intraperitoneally pretreated with a single dose 100 pg of an anti-mouse IL-9 .

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