tailieunhanh - Báo cáo khoa học: "Sequence analysis of dolphin ferritin H and L subunits and possible iron-dependent translational control of dolphin ferritin gene"

Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú y đề tài: Sequence analysis of dolphin ferritin H and L subunits and possible iron-dependent translational control of dolphin ferritin gene. | Acta Veterinaria Scandinavica BioMed Central Research Sequence analysis of dolphin ferritin H and L subunits and possible iron-dependent translational control of dolphin ferritin gene Azusa Takaesu1 Kiyotaka Watanabe1 Shinji Takai2 Yukako Sasaki2 and Koichi Orino 1 Open Access Address laboratories of Veterinary Biochemistry School of Veterinary Medicine Kitasato University Aomori 034-8628 Japan and 2Animal Hygiene School of Veterinary Medicine Kitasato University Aomori 034-8628 Japan Email Azusa Takaesu - azu147@ Kiyotaka Watanabe - watanebe@ ShinjiTakai - takai@ Yukako Sasaki - yukako@ Koichi Orino - orino@ Corresponding author Published 27 October 2008 Received 12 June 2008 Acta Veterinaria Scandinavica 2008 50 42 doi l75l-0l47-50-42 Accepted 27 October 2008 This article is available from http content 50 1 42 2008 Takaesu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Iron-storage protein ferritin plays a central role in iron metabolism. Ferritin has dual function to store iron and segregate iron for protection of iron-catalyzed reactive oxygen species. Tissue ferritin is composed of two kinds of subunits H heavy chain or heart-type subunit L light chain or liver-type subunit . Ferritin gene expression is controlled at translational level in iron-dependent manner or at transcriptional level in iron-independent manner. However sequencing analysis of marine mammalian ferritin subunits has not yet been performed fully. The purpose of this study is to reveal cDNA-derived amino acid sequences of cetacean ferritin H and L subunits and demonstrate the possibility of expression of