tailieunhanh - Báo cáo y học: "Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury. | Respiratory Research BioMed Central Research Open Access Deficiency in type I insulin-like growth factor receptor in mice protects against oxygen-induced lung injury Karmene Ahamed11 Ralph Epaud11 Martin Holzenberger2 Monique Bonora1 Jean-Franẹois Flejou3 Julien Puard1 Annick Clement1 and Alexandra Henrion-Caude 1 Address 1INSERM U719 Hospital Saint-Antoine 75012 Paris France 2INSERM U515 Hospital Saint-Antoine 75012 Paris France and 3Department of Pathology Hospital Saint-Antoine 75012 Paris France Email Karmene Ahamed - ahamed@ Ralph Epaud - Martin Holzenberger - holzenberger@ Monique Bonora - bonora@ Jean-Franẹois Flejou - Julien Puard - puard@ Annick Clement - Alexandra Henrion-Caude - caude@ Corresponding author fEqual contributors Published 08 April 2005 Received 21 January 2005 Respiratory Research 2005 6 31 doi 1465-9921 -6-31 Accepted 08 April 2005 This article is available from http content 6 1 3 1 2005 Ahamed et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cellular responses to aging and oxidative stress are regulated by type 1 insulin-like growth factor receptor IGF-1R . Oxidant injury which is implicated in the pathophysiology of a number of respiratory diseases acutely upregulates IGF-1R expression in the lung. This led us to suspect that reduction of IGF-1R levels in lung tissue could prevent deleterious effects of oxygen exposure. Methods Since IGF-1R null mutant mice die at birth from respiratory failure we generated compound heterozygous mice harboring a hypomorphic Igf-lrneo and