tailieunhanh - Báo cáo y học: " Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models. | Respiratory Research BioMed Central Research Open Access Is neutrophil elastase the missing link between emphysema and fibrosis Evidence from two mouse models Monica Lucattelli Barbara Bartalesi Eleonora Cavarra Silvia Fineschi Benedetta Lunghi Piero A Martorana and Giuseppe Lungarella Address Department of Physiopathology Experimental Medicine University of Siena 53100 Siena Italy Email Monica Lucattelli - lucattelli@ Barbara Bartalesi - bartalesi@ Eleonora Cavarra - cavarra@ Silvia Fineschi - fineschi2@ Benedetta Lunghi - lunghi@ Piero A Martorana - martorana@ Giuseppe Lungarella - lungarella@ Corresponding author Published 26 July 2005 Received 29 April 2005 Respiratory Research 2005 6 83 doi 1465-9921 -6-83 Accepted 26 July 2005 This article is available from http content 6 1 83 2005 Lucattelli et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The separation of emphysema from fibrosis is not as clear-cut as it was thought in early studies. These two pathologies may be present at the same time in human lungs and in mice either instilled with elastolytic enzymes or bleomycin or exposed to cigarette-smoke. According to a current view emphysema originates from a protease antiprotease imbalance and a role for antiproteases has also been suggested in the modulation of the fibrotic process. In this study we investigate in experimental animal models of emphysema and fibrosis whether neutrophil elastase may constitute a pathogenic link between these two pathologies. Methods This study was done in two animal models in which emphysema and fibrosis were induced either by bleomycin BLM or by chronic exposure to .