tailieunhanh - Báo cáo y học: "Chronic pneumonia with Pseudomonas aeruginosa and impaired alveolar fluid clearance"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Chronic pneumonia with Pseudomonas aeruginosa and impaired alveolar fluid clearance. | Respiratory Research BioMed Central Research Open Access Chronic pneumonia with Pseudomonas aeruginosa and impaired alveolar fluid clearance Sophie Boyer1 Karine Faure1 Florence Ader1 Marie Odile Husson2 Eric Kipnis1 Thierry Prangere3 Xavier Leroy4 and Benoit P Guery 1 Address 1Laboratoire de recherche en Pathologie Infectieuse EA 2689. Faculté de Médecine de Lille 59031 Lille Cedex France 2Laboratoire de Bactériologie Hôpital Calmette CHRU de Lille Lille France 3Laboratoire de Biophysique CHRU Lille France and 4Laboratoire d anatomo-pathologie CHRU Lille France Email Sophie Boyer - Karine Faure - karine-faure@ Florence Ader - fader@ Marie Odile Husson - MOHUSSON@ Eric Kipnis - ekipnis@ Thierry Prangere - Xavier Leroy - XAVIERLEROY1@ Benoit P Guery - bguery@ Corresponding author Published II February 2005 Received 21 October 2004 Respiratory Research 2005 6 17 doi 1465-9921-6-17 Accepted 11 February 2005 This article is available from http content 6 1 17 2005 Boyer et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background While the functional consequences of acute pulmonary infections are widely documented few studies focused on chronic pneumonia. We evaluated the consequences of chronic Pseudomonas lung infection on alveolar function. Methods P. aeruginosa included in agar beads was instilled intratracheally in Sprague Dawley rats. Analysis was performed from day 2 to 21 a control group received only sterile agar beads. Alveolar-capillary barrier permeability lung liquid clearance LLC and distal alveolar fluid clearance DAFC were measured using a vascular 131I-Albumin and an .