tailieunhanh - Báo cáo y học: "The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo. | Respiratory Research BioMed Central Research Open Access The beta2 integrin CDIIc distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo Marc Beyer1 2 Hongwei Wang1 Nina Peters1 Sandra Doths2 Cordula Koerner-Rettberg2 Peter JM Openshaw1 and Jurgen Schwarze 1 2 Address Department of Respiratory Medicine NHLI Imperial College London Norfolk Place London UK and 2Klinik fur Kinder- und Jugendmedizin St. Josef-Hospital Ruhr-Universitat Bochum Alexandrinenstr. 3 44791 Bochum Germany Email Marc Beyer - Hongwei Wang - Nina Peters - Sandra Doths - Cordula Koerner-Rettberg - Peter JM Openshaw - Jurgen Schwarze - Corresponding author Published 12 July 2005 Received 14 September 2004 Respiratory Research 2005 6 70 doi 1465-9921 -6-70 Accepted 12 July 2005 This article is available from http content 6 1 70 2005 Beyer et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The integrin CD11c is known as a marker for dendritic cells and has recently been described on T cells following lymphotropic choriomeningitis virus infection a systemic infection affecting a multitude of organs. Here we characterise CD11c bearing T cells in a murine model of localised pulmonary infection with respiratory syncytial virus RSV . Methods Mice were infected intranasally with RSV and expression of P2 integrins and T lymphocyte activation markers were monitored by flow cytometry. On day 8 post RSV infection CD11c CD8 and CD11c- CD8 T cells were assessed for