tailieunhanh - Báo cáo y học: "Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice. | Respiratory Research BioMed Central Research Open Access Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice Rosanna Di Paola 1 Emanuela Mazzon1 Carmelo Muià1 Tiziana Genovese1 Marta Menegazzi2 Raffaela Zaffini2 Hisanory Suzuki2 and Salvatore Cuzzocrea 1 Address Department of Clinical and Experimental Medicine and Pharmacology Torre Biologica Policlinico Universitario Messina Italy and 2Biochemistry Division Department of Neuroscience and Vision University of Verona Verona Italy Email Rosanna Di Paola - salvator@ Emanuela Mazzon - salvator@ Carmelo Muià - salvator@ Tiziana Genovese - salvator@ Marta Menegazzi - salvator@ Raffaela Zaffini - salvator@ Hisanory Suzuki - salvator@ Salvatore Cuzzocrea - salvator@ Corresponding author Published 29 June 2005 Received 21 April 2005 Respiratory Research 2005 6 66 doi 1465-9921 -6-66 Accepted 29 June 2005 This article is available from http content 6 1 66 2005 Di Paola et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Here we investigate the effects of the green tea extract in an animal model of acute inflammation carrageenan-induced pleurisy. We report here that green tea extract given at 25 mg kg . bolus 1 h prior to carrageenan exerts potent anti-inflammatory effects in an animal model of acute inflammation in vivo. Injection of carrageenan 2 into the pleural cavity of mice elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity that contained many neutrophils PMNs an infiltration of PMNs in lung tissues and increased production of nitrite nitrate tumour necrosis .