tailieunhanh - Báo cáo y học: "Mathematical modelling to centre low tidal volumes following acute lung injury: A study with biologically variable ventilation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Mathematical modelling to centre low tidal volumes following acute lung injury: A study with biologically variable ventilatio. | Respiratory Research BioMed Central Research Open Access Mathematical modelling to centre low tidal volumes following acute lung injury A study with biologically variable ventilation M Ruth Graham11 Craig J Haberman1 John F Brewster2 Linda G Girling1 Bruce M McManus3 and W Alan C Mutch 11 Address Department of Anesthesia University of Manitoba Winnipeg Manitoba Canada 2Institute of Industrial Mathematical Sciences University of Manitoba Winnipeg Manitoba Canada and 3Department of Pathology and Laboratory Medicine James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research University of British Columbia Vancouver British Columbia Canada Email M Ruth Graham - mrgraha@ Craig J Haberman - chabs@ John F Brewster - john_brewster@ Linda G Girling - girling1@ Bruce M McManus - bmcmanus@ W Alan C Mutch - amutch@ Corresponding author fEqual contributors Published 28 June 2005 Received 01 April 2005 Respiratory Research 2005 6 64 doi 1465-9921 -6-64 Accepted 28 June 2005 This article is available from http content 6 1 64 2005 Graham et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background With biologically variable ventilation BVV - using a computer-controller to add breath-to-breath variability to respiratory frequency f and tidal volume VT gas exchange and respiratory mechanics were compared using the ARDSNet low VT algorithm Control versus an approach using mathematical modelling to individually optimise VT at the point of maximal compliance change on the convex portion of the inspiratory pressure-volume P-V curve Experimental . Methods Pigs n 22 received pentothal midazolam anaesthesia oleic acid .