tailieunhanh - Báo cáo y học: " Models of chronic obstructive pulmonary disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Models of chronic obstructive pulmonary disease. | Respiratory Research BioMed Central Review Models of chronic obstructive pulmonary disease David A Groneberg 1 and K Fan Chung2 Open Access Address 1Pneumology and Immunology Otto-Heubner-Centre Charité School of Medicine Free University and Humboldt-University Berlin Germany and 2Thoracic Medicine National Heart Lung Institute Imperial College London UK Email David A Groneberg - K Fan Chung - Corresponding author Published 02 November 2004 Received 28 July 2004 Accepted 02 November 2004 Respiratory Research 2004 5 18 doi 1465-9921-5-18 This article is available from http content 5 1 18 2004 Groneberg and Chung licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Chronic obstructive pulmonary disease COPD is a major global health problem and is predicted to become the third most common cause of death by 2020. Apart from the important preventive steps of smoking cessation there are no other specific treatments for COPD that are as effective in reversing the condition and therefore there is a need to understand the pathophysiological mechanisms that could lead to new therapeutic strategies. The development of experimental models will help to dissect these mechanisms at the cellular and molecular level. COPD is a disease characterized by progressive airflow obstruction of the peripheral airways associated with lung inflammation emphysema and mucus hypersecretion. Different approaches to mimic COPD have been developed but are limited in comparison to models of allergic asthma. COPD models usually do not mimic the major features of human COPD and are commonly based on the induction of COPD-like lesions in the lungs and airways using noxious .